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‘Unprecedented risk’ to life on Earth: Scientists call for halt on ‘mirror life’ microbe research • The Guardian

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Ian Sample:

World-leading scientists have called for a halt on research to create “mirror life” microbes amid concerns that the synthetic organisms would present an “unprecedented risk” to life on Earth. The international group of Nobel laureates and other experts warn that mirror bacteria, constructed from mirror images of molecules found in nature, could become established in the environment and slip past the immune defences of natural organisms, putting humans, animals and plants at risk of lethal infections. Although a viable mirror microbe would probably take at least a decade to build, a new risk assessment raised such serious concerns about the organisms that the 38-strong group urged scientists to stop work towards the goal and asked funders to make clear they will no longer support the research. “The threat we’re talking about is unprecedented,” said Prof Vaughn Cooper, an evolutionary biologist at the University of Pittsburgh. “Mirror bacteria would likely evade many human, animal and plant immune system responses and in each case would cause lethal infections that would spread without check.” The expert group includes Dr Craig Venter, the US scientist who led the private effort to sequence the human genome in the 1990s, and the Nobel laureates Prof Greg Winter at the University of Cambridge and Prof Jack Szostak at the University of Chicago. Many molecules for life can exist in two distinct forms, each the mirror image of the other. The DNA of all living organisms is made from “right-handed” nucleotides, while proteins, the building blocks of cells, are made from “left-handed” amino acids. Why nature works this way is unclear: life could have chosen left-handed DNA and right-handed proteins instead. …The fresh concerns over the technology are revealed in a 299-page report and a commentary in the journal Science. While enthusiastic about research on mirror molecules, the report sees substantial risks in mirror microbes and calls for a global debate on the work.

For Venter to be against this is quite something: he has usually been the one barnstorming along, ignoring the consensus.
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14 days ago
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The Death of Search

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For nearly two years, the world’s biggest tech companies have said that AI will transform the web, your life, and the world. But first, they are remaking the humble search engine.

Chatbots and search, in theory, are a perfect match. A standard Google search interprets a query and pulls up relevant results; tech companies have spent tens or hundreds of millions of dollars engineering chatbots that interpret human inputs, synthesize information, and provide fluent, useful responses. No more keyword refining or scouring Wikipedia—ChatGPT will do it all. Search is an appealing target, too: Shaping how people navigate the internet is tantamount to shaping the internet itself.

Months of prophesying about generative AI have now culminated, almost all at once, in what may be the clearest glimpse yet into the internet’s future. After a series of limited releases and product demos, mired with various setbacks and embarrassing errors, tech companies are debuting AI-powered search engines as fully realized, all-inclusive products. Last Monday, Google announced that it would launch its AI Overviews in more than 100 new countries; that feature will now reach more than 1 billion users a month. Days later, OpenAI announced a new search function in ChatGPT, available to paid users for now and soon opening to the public. The same afternoon, the AI-search start-up Perplexity shared instructions for making its “answer engine” the default search tool in your web browser.

[Read: The AI search war has begun]

For the past week, I have been using these products in a variety of ways: to research articles, follow the election, and run everyday search queries. In turn I have scried, as best I can, into the future of how billions of people will access, relate to, and synthesize information. What I’ve learned is that these products are at once unexpectedly convenient, frustrating, and weird. These tools’ current iterations surprised and, at times, impressed me, yet even when they work perfectly, I’m not convinced that AI search is a wise endeavor.

For decades, the search bar has been a known entity. People around the world are accustomed to it; several generations implicitly regard Google as the first and best way to learn about basically anything. Enter a query, sift through a list of links, type a follow-up query, get more links, and so on until your question is answered or inquiry satisfied. That indirectness and wide aperture—all that clicking and scrolling—are in some ways the defining qualities of a traditional Google search, allowing (even forcing) you to traverse the depth and breadth of connections that justify the term world-wide web. The hyperlink, in this sense, is the building block of the modern internet.

That sprawl is lovely when you are going down a rabbit hole about Lucrezia de Medici, as I did when traveling in Florence last year, or when diving deep into a scientific dilemma. It is perfect for stumbling across delightful video clips and magazine features and social-media posts. And it is infuriating when you just need a simple biographical answer, or a brunch recommendation without the backstory of three different chefs, or a quick gloss of a complex research area without having to wade through obscure papers.

In recent years, more and more Google Search users have noted that the frustrations outweigh the delight—describing a growing number of paid advertisements, speciously relevant links engineered to top the search algorithm, and erroneous results. Generative AI promises to address those moments of frustration by providing a very different experience. Asking ChatGPT to search the web for the reasons Kamala Harris lost the presidential election yielded a short list with four factors: “economic concerns,” “demographic shifts,” “swing state dynamics,” and “campaign strategies.” It was an easy and digestible response, but not a particularly insightful one; in response to a follow-up question about voter demographics, ChatGPT provided a stream of statistics without context or analysis. A similar Google search, meanwhile, pulls up a wide range of news analyses that you have to read through. If you do follow Google’s links, you will develop a much deeper understanding of the American economy and politics.

Another example: Recently, I’ve been reading about a controversial proposed infrastructure project in Maryland. Google searches sent me through a labyrinth of public documents, corporate pitches, and hours-long recordings of city-council meetings, which took ages to review but sparked curiosity and left me deeply informed. ChatGPT, when asked, whipped up an accurate summary and timeline of events, and cited its sources—which was an extremely useful way to organize the reading I’d already done, but on its own might have been the end of my explorations.

I have long been a critic of AI-powered search. The technology has repeatedly fabricated information and struggled to accurately attribute its sources. Its creators have been accused of plagiarizing and violating the intellectual-property rights of major news organizations. None of these concerns has been fully allayed: The new ChatGPT search function, in my own use and other reports, has made some errors, mixing up dates, misreporting sports scores, and telling me that Brooklyn’s Prospect Park is bigger than Manhattan’s (much larger) Central Park. The links offered by traditional search engines are filled with errors too—but searchbots implicitly ask for your trust without verification. The citations don’t particularly invite you to click on them. And while OpenAI and Perplexity have entered into partnerships with any number of media organizations, including The Atlantic—perhaps competing for the high-quality, human-made content that their searchbots depend on—exactly how websites that once relied on ad revenue and subscriptions will fare on an AI-filtered web eludes me. (The editorial division of The Atlantic operates independently from the business division, which announced its corporate partnership with OpenAI in May.)

[Read: AI search is turning into the problem everyone worried about]

Although ChatGPT and Perplexity and Google AI Overviews cite their sources with (small) footnotes or bars to click on, not clicking on those links is the entire point. OpenAI, in its announcement of its new search feature, wrote that “getting useful answers on the web can take a lot of effort. It often requires multiple searches and digging through links to find quality sources and the right information for you. Now, chat can get you to a better answer.” Google’s pitch is that its AI “will do the Googling for you.” Perplexity’s chief business officer told me this summer that “people don’t come to Perplexity to consume journalism,” and that the AI tool will provide less traffic than traditional search. For curious users, Perplexity suggests follow-up questions so that, instead of opening a footnote, you keep reading in Perplexity.

The change will be the equivalent of going from navigating a library with the Dewey decimal system, and thus encountering related books on adjacent shelves, to requesting books for pickup through a digital catalog. It could completely reorient our relationship to knowledge, prioritizing rapid, detailed, abridged answers over a deep understanding and the consideration of varied sources and viewpoints. Much of what’s beautiful about searching the internet is jumping into ridiculous Reddit debates and developing unforeseen obsessions on the way to mastering a topic you’d first heard of six hours ago, via a different search; falling into clutter and treasure, all the time, without ever intending to. AI search may close off these avenues to not only discovery but its impetus, curiosity.

The issues with factuality and attribution may well be resolved—but even if they aren’t, tech companies show no signs of relenting. Controlling search means controlling how most people access every other digital thing—it’s an incredible platform to gain trust and visibility, advertise, or influence public opinion.

The internet is changing, and nobody outside these corporations has any say in it. And the biggest, most useful, and most frightening change may come from AI search engines working flawlessly. With AI, the goal is to keep you in one tech company’s ecosystem—to keep you using the AI interface, and getting the information that the AI deems relevant and necessary. The best searches are goal-oriented; the best responses are brief. Which perhaps shouldn’t be surprising coming from Silicon Valley behemoths that care, above all, about optimizing their businesses, products, and users’ lives.

A little, or even a lot, of inefficiency in search has long been the norm; AI will snuff it out. Our lives will be more convenient and streamlined, but perhaps a bit less wonderful and wonder-filled, a bit less illuminated. A process once geared toward exploration will shift to extraction. Less meandering, more hunting. No more unknown unknowns. If these companies really have their way, no more hyperlinks—and thus, no actual web.

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stevereally
46 days ago
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Of interest.
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Trump told his nephew to just let his disabled son die

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The party of life:

The meeting I had assumed would be a quick handshake hello with Donald had turned into a 45-minute discussion in the Oval Office with all of us—Azar, Giroir, the advocates, and me. I never expected to be there so long. Donald seemed engaged, especially when several people in our group spoke about the heart-wrenching and expensive efforts they’d made to care for their profoundly disabled family members, who were constantly in and out of the hospital and living with complex arrays of challenges.

Donald was still Donald, of course. He bounced from subject to subject—disability to the stock market and back to disability. But promisingly, Donald seemed genuinely curious regarding the depth of medical needs across the U.S. and the individual challenges these families faced. He told the secretary and the assistant secretary to stay in touch with our group and to be supportive. 

After I left the office, I was standing with the others near the side entrance to the West Wing when Donald’s assistant caught up with me. “Your uncle would like to see you,” she said.

Azar was still in the Oval Office when I walked back in. “Hey, pal,” Donald said. “How’s everything going?”

“Good,” I said. “I appreciate your meeting with us.”

“Sure, happy to do it.”

He sounded interested and even concerned. I thought he had been touched by what the doctor and advocates in the meeting had just shared about their journey with their patients and their own family members. But I was wrong.

“Those people . . . ” Donald said, trailing off. “The shape they’re in, all the expenses, maybe those kinds of people should just die.” 

I truly did not know what to say. He was talking about expenses. We were talking about human lives. For Donald, I think it really was about the expenses, even though we were there to talk about efficiencies, smarter investments, and human dignity.

I turned and walked away.

If you think it can’t get worse than that you would be wrong:

Eric said he’d been getting some resistance from Maryanne, Elizabeth, and Ann Marie, Robert’s widow. I really didn’t look forward to these calls.

“Why don’t you call Donald?” Eric said. “Talk to him about it.”

I thanked Eric for the heads-up and promised I would.

Soon thereafter, I was up at Briarcliff Manor, home of the Trump National Golf Club in Westchester, N.Y. Donald happened to be there.

He was talking with a group of people. I didn’t want to interrupt. I just said hi on my way through the clubhouse. I called him later that afternoon, and he answered.

I got him up to speed on what Eric had told me. I said I’d heard the fund for William was running low, and unfortunately, the expenses certainly were not easing up as our son got older. In fact, with inflation and other pressures, the needs were greater than they’d been. “We’re getting some blowback from Maryanne and Elizabeth and Ann Marie. We may need your help with this. Eric wanted me to give you a call.”

Donald took a second as if he was thinking about the whole situation.

“I don’t know,” he finally said, letting out a sigh. “He doesn’t recognize you. Maybe you should just let him die and move down to Florida.”

Wait! What did he just say? That my son doesn’t recognize me? That I should just let him die?

Did he really just say that? That I should let my son die . . . so I could move down to Florida?

Really?

I’m usually pretty good at getting my head around things that other people say, even when I don’t agree with them. But this was a tough one. This was my son.

Maybe I shouldn’t have been surprised to hear Donald say that. It wasn’t far off from what he’d said that day in the Oval Office after our meeting with the advocates. Only that time, it was other people’s children who should die. This time, it was my son.

45% (at least) of the American voting public is going to cast its ballots for this psychopath.

The post Trump told his nephew to just let his disabled son die appeared first on Lawyers, Guns & Money.

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157 days ago
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Deadpool & Wolverine Finds the Fun in Corporate Compliance

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In his new film, the Marvel world’s resident bad-boy makes nice with his new corporate overlords.
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158 days ago
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Want to See a Snake Eat Its Tail?

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The first Deadpool film, released in 2016, broke lots of rules. It was R-rated and hyper-violent, but it was also self-aware in the Family Guy way, frequently puncturing the fourth wall and mocking the seriousness of the superhero genre. Deadpool, played by Ryan Reynolds, knew he was in a movie—and a dumb one, at that. This intentionally juvenile humor bred massive success, and by 2018’s Deadpool 2, our quippy antihero knew he was in a cinematic universe—albeit the junky one run by 20th Century Studios that quivered alongside the ruthless success of Disney’s Marvel enterprise. (For those of you who haven’t relentlessly kept up: The film rights to the different Marvel superheroes are owned by different studios, and it’s generally accepted that Marvel Studios—which is owned by Disney—has made the better movies.)

Times change, corporate acquisitions happen, and now we have Deadpool & Wolverine, in which Deadpool not only knows he’s in a cinematic universe but also wants to go to a better one. It’s an almost entirely metatextual movie—a series of Variety articles given life, crammed in a Lycra suit and encouraged to curse with impunity. Shawn Levy’s film exists to properly usher Deadpool into Disney’s squeaky-clean Marvel Cinematic Universe, helped along by the wearily professional Wolverine (Hugh Jackman), dragged out of retirement (and death) for one last rodeo. But Deadpool & Wolverine is also a gleeful funeral for all the stunted series and cinematic universes the MCU has squashed over the years, even referencing long-rumored projects that never came to fruition.

Yes, the film is razzing the corporate frameworks around these beloved (or sometimes despised) enterprises. But it also assumes that audiences know as much as Deadpool does inside his own movie. Deadpool is very aware that the MCU mastermind Kevin Feige is his new producer, that his jokes about cocaine won’t fly under Disney’s radar, and that Hugh Jackman is both too old for this nonsense and very good at singing Broadway numbers. At times, the movie more resembles a jokey sizzle reel at CinemaCon than it does actual cinema. For viewers who spend a lot of their time online, soaking up the discourse generated by insider-fan accounts and message boards, all of this will seem warmly familiar. But good luck if you’re coming in with no prior knowledge.

Nevertheless. Feige’s mainstream instincts are easy to detect here. The prior Deadpool films were scuzzy and cobbled together, even as the budget grew; the cameos from other Marvel characters felt half-hearted and perfunctory, inclusions for Deadpool to roll his eyes at, not for fans to cheer over. Deadpool & Wolverine, on the other hand, has that bland MCU sheen that makes all of its movies look expensive but nonthreatening, happily accepting of mediocrity rather than attempting something artsy or daring. Similarly, what passes for the narrative stakes have been honed to fan-service perfection, with characters spouting sci-fi gibberish about how characters such as Wolverine are “anchor entities” that keep universes going, essentially proclaiming that superheroes are the most important things imaginable.

The MCU has undoubtedly lost some commercial and critical momentum, but because Deadpool & Wolverine is so firmly focused on satisfying the nerds, I predict it’ll crush at the box office. The familiar presences of Reynolds and Jackman will definitely help; I’ve certainly grown tired of the former’s motor-mouthed wisecracking in every single movie, but he’s very comfortable with Deadpool’s profane monologues. Jackman, meanwhile, can deliver gravitas in his sleep, even as his role here diminishes the glorious swan song he received in 2017’s Logan, in which he sort of went out like Clint Eastwood. (Deadpool & Wolverine is aware of this too, and makes several jokes about it.)

[Read: The Dark Knight changed Hollywood forever]

Shall I attempt to describe the plot of this jokey mash of cutaway gags and PowerPoints? Very well. Deadpool, a scarred mercenary with a healing factor, has largely drifted toward retirement and a life of hanging out with his pals from the previous two movies. But then he’s tossed into a cosmic in-between zone run by the Time Variance Authority (from, uh, TV’s Loki), the bureaucrats managing every cinematic universe seen and unseen. A fussy stuffed suit named Mr. Paradox (Matthew Macfadyen) tells Deadpool that his world is vanishing and irrelevant, but that he’s been chosen for a brighter future: the MCU, where mysterious overlords have decided he belongs. So he goes on a timeline-hopping adventure, assisted by a particularly drunk and miserable Wolverine on the way, to try to save his friends from deletion.

My head hurt typing that out, and it’s probably just as inscrutable to read, but it also doesn’t really matter. Deadpool is here, Wolverine is grunting alongside him, and they stab lots of folks and make lots of jokes while exciting actors make nostalgic cameo appearances. It’s a movie that’s playing to the back of the house—assuming the house is Comic-Con’s Hall H—and it’ll get lots of laughs in return. Can Deadpool himself save the faltering MCU? Probably not. But with four more MCU movies slated for release in 2025, it’s a little relieving to watch someone poke fun at how pompous they’ve become—as much fun as Feige allows, that is.

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Where Should the Sundance Film Festival Go Next?

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Photo-Illustration: Vulture; Photos: Getty Images

Like the character that gave the festival its name, Sundance may be about to take a big leap into the unknown.

After 40 years in Park City, Utah, the Sundance Film Festival announced in April that it was welcoming bids for a potential new home starting in January 2027. The festival has played down the reasons for leaving its longtime host, citing only a desire to ensure that “inclusivity and sustainability are always at the forefront.” Reading between the lines, the former seems a reference to anti-LGBTQ laws recently passed by the Utah state legislature, the latter an acknowledgment that Sundance may have outgrown Park City, a town of 8,000 that sees its entire Main Street booked for private events for the duration of the festival, leaving hardworking journalists no other option but to sustain themselves on grocery-store sushi for a week. But I digress!

Fifteen cities reportedly applied to be Sundance’s new home, and last week the festival officially narrowed its search to six finalists. Left off the list were hopefuls like Minneapolis (even colder than Utah), Athens (doesn’t have an airport), Savannah (already has the SCAD Film Festival), and Nashville (not really a film town; it’s more Hawk Tuah than Talk to Her). Sorry to all of them; perhaps they’ll have better luck applying to be the new hosts of Cannes.

A selection committee will visit each of the remaining contenders over the next few weeks, which should absolutely be the setup for a short-form documentary series. But before any final decision is made, it’s imperative that Sundance hear from a very important stakeholder — me. As a festival connoisseur who has learned to type an entire blog post on my phone in between bites of a chicken Caesar wrap, which city would I most like to spend a week rushing between theaters, trying to catch three, four, or even five movies a day?

The contenders will be judged on the following statistical criteria:

— What’s the weather like in January?

— How easy is it to get there, and once I’m there, how easy is it to get around?

— How much of Vox Media’s money will I be squandering to get a decent Airbnb?

— Can I get a tasty, moderately healthy meal in a 45-minute gap between screenings?

— Are there enough movie theaters to host a full-size festival? (Note that this is not necessarily disqualifying: One of the defining experiences of Sundance and Telluride is watching a premiere in a high-school auditorium or a converted ice-hockey rink.)

In addition, I will also offer a more amorphous vibes-based judgment. That the festival is keepings its traditional January date indicates it will attempt to maintain its role as an indie showcase that stands outside the winter awards circus. So we must also ask how well each prospective host fits with the established Sundance atmosphere. I want my celebs doing their Chase Sapphire Lounge photo shoots in quirky sweaters and the world’s most gigantic puffers. I want flat-brimmed hats and big ol’ boots. Sundance should not be Santa Barbara. A sense of being cut off from the outside world is a plus, as is a vague (and false) feeling of roughing it.

Is the grass always greener bluer on the other side? Let’s run down the likely candidates:

6. Louisville

Photo: Getty Images

Average January temperature: 36 degrees.

Flight time from NYC: About two and a half hours.

Flight time from L.A.: There are no direct flights; it’s around six hours with a layover.

Average per-night cost of a “guest favorite” 1BR on Airbnb: $130

Will I need to Uber everywhere? Public transit is “terrible, often late, and difficult to make connections.”

Are there copious fast-casual restaurants? Apparently, there’s a food hall downtown. And, of course, there’s also the Hot Brown, a riff on the Welsh rarebit that’s basically an open-faced turkey sandwich topped with bacon and Mornay sauce, which I would absolutely need to try.

How many movie theaters are there already? Not many, though there are a couple performing-arts venues downtown that could be converted. Funnily enough, one local landmark is a marquee for a movie theater that no longer exists.

Louisville is only 100 miles away from another finalist, and they’re both in the same liminal region: not quite the Midwest, not quite Appalachia, and not quite the South. So it’s kind of funny that Sundance put both of them through to the finals, and even Louisvillians aren’t quite sure how they made the cut. (Conspiracy brain: Since Kentucky’s LGBT-rights rating is even worse than Utah’s, either the inclusivity thing is a red herring, or Sundance is stacking the field with red-state tomato cans to clear a path for the two cities it really wants.) Anyway, I guess the best argument you can make for Louisville is that it’s temperate and used to accommodating visitors. The local culture here seems mostly built around whiskey and horse racing, which doesn’t feel super Sundance-y to me.

5. Cincinnati

Photo: Getty Images

Average January temperature: 31 degrees.

Flight time from NYC: About two hours.

Flight time from L.A.: The only nonstop option is a Delta red-eye, if you’re up for it. Otherwise, you’re looking at a layover and a six-hour journey.

Average per-night cost of a “guest favorite” 1BR on Airbnb: $98, which is also the number of degrees in the city’s most famous band.

Will I need to Uber everywhere? Consensus says public transit is “not that bad.”

Are there copious fast-casual restaurants? I am perhaps the only member of the East Coast media elite willing to defend Cincinnati chili, but I would not want to eat it more than once a week. Anyway, it seems like most of the places worth checking out are around the university, not downtown.

How many movie theaters are there already? There’s only one theater downtown, though as with other finalists, there are a few performing-arts venues that could accommodate film screenings.

I used to live in Cincinnati. Here’s my review: good playgrounds, excellent Chuck E. Cheese, gigantic kindergarteners. (I was a toddler.) I haven’t been back since I learned how to read, so I boned up on the copious “Louisville vs. Cincinnati” posts online to see which to rank higher. Cincy seems to edge it in terms of infrastructure and vibrancy, but let’s be honest — unless one of them knocks the pitch out of the park (which would be great for the aforementioned short-form doc), Sundance probably isn’t choosing either of these random midsize red-state cities.

4. Salt Lake City

Photo: Getty Images

Average January temperature: 31 degrees.

Flight time from NYC: Around five hours.

Flight time from L.A.: Around two hours.

Average per-night cost of a “guest favorite” 1BR on Airbnb: $80.

Will I need to Uber everywhere? There’s a light-rail system called TRAX and a bus network. Residents hail the public transit as “reliable.”

Are there copious fast-casual restaurants? Enough to fill up an entire online listicle!

How many movie theaters are there already? There are a few multiplexes downtown.

This is actually a hybrid bid for Sundance to be jointly based in Park City and Salt Lake City, with the assumption that the larger locale would pick up more of the slack. Essentially, it’s the continuity option: SLC has hosted Sundance in the past, and the festival already schedules multiple events downtown. (Plus, unless you’re among the PJ set, you fly in here anyway.) There is an argument that SLC is the best of both worlds. It gives the festival all the infrastructure of a proper city while still feeling indisputably Sundance-y. Reporters would barely have to change their tweets! However, the home of the Jazz comes with one major sticking point. If Sundance really does want to leave Park City because of Utah’s anti-trans laws, simply moving 30 miles down the road won’t cut it.

3. Atlanta

Photo: Sean Pavone/Getty Images

Average January temperature: 44 degrees.

Flight time from NYC: Over two hours. (In fact, 80 percent of the U.S. population lives within a two-hour flight of the Atlanta airport.)

Flight time from L.A.: Sorry, L.A., you’re in the 20 percent. It’s about four hours.

Average per-night cost of a “guest favorite” 1BR on Airbnb: $120.

Will I need to Uber everywhere? Atlanta has the MARTA rail network, which is underwhelming.

Are there copious fast-casual restaurants? When I was a kid, I used to love the Varsity, and the city is now a pioneer in the grain-bowl space.

How many movie theaters are there already? This is the eighth-largest metro region in the entire country, so there are a bunch.

Over the past decade, Atlanta has become a center for film and TV production. I’ve heard from people who work there that they often feel left behind or ignored by the power centers on the coasts. Sundance coming to town would fundamentally change Atlanta’s relationship with the industry. Considering that what gets made there is usually more commercial than the typical Sundance fare, it would also fundamentally alter the nature of the festival itself. This would be the opposite of sticking with Utah — a vote for Atlanta is a vote for radical change. (It’s worth noting that Georgia’s record on LGBTQ issues isn’t great, either.)

2. Santa Fe

Photo: Getty Images

Average January temperature: 30 degrees.

Flight time from NYC: No direct flights; it’s around seven hours with a layover. You could also fly into Albuquerque, which is an hour away, but there are no direct flights there from New York, either.

Flight time from L.A.: Albuquerque is only a two-hour flight. Flying into Santa Fe requires a layover, making it a four- to five-hour journey.

Average per-night cost of a “guest favorite” 1BR on Airbnb: $170.

Will I need to Uber everywhere? There are buses, but they’re slow and not always reliable.

Are there copious fast-casual restaurants? Are breakfast burritos and green-chile burgers necessarily conducive to a lifestyle where you’re sitting in a movie theater nine hours a day? Perhaps not, but who cares.

How many movie theaters are there already? A couple independent theaters downtown — one of which is owned by George R.R. Martin — and a Regal in a mall about 15 minutes away.

It’s really expensive and a trek for New Yorkers. But otherwise, there’s a lot to recommend about Santa Fe, including a thriving local arts scene and the scale that’s ideal for a festival town: small enough to feel cloistered in a world of pure cinema, big enough to handle an influx of dorks in lanyards. I sense that the local vibe is kind of kooky, which is worth a lot of points in my book.

1. Boulder

Photo: Getty Images/Getty Images

Average January temperature: 34 degrees.

Flight time from NYC: Around four hours to Denver, which is 45 minutes away by car.

Flight time from L.A.: Over two hours to the Denver airport.

Average per-night cost of a “guest favorite” 1BR on Airbnb: There are almost no such 1BRs in Boulder on Airbnb.

Will I need to Uber everywhere? Transit is decent, and many residents say they’re able to get by without a car.

Are there copious fast-casual restaurants? Alongside cannabis shops, Patagonia fleece, and microbrews, my mental image of Boulder includes health-conscious fast-casual dining, and I’m pleased to report that the stereotype is correct.

How many movie theaters are there already? There’s the Art Deco Boulder Theater downtown and a Cinemark a mile away.

Boulder is the Goldilocks pick. It’s got the same small-city vibe as Santa Fe, but it’s cheaper and easier to get to. It’s conveniently located next to, but not in, a major urban center. If my map is correct, Colorado is only one state over from Utah, so the aesthetic won’t change too much. And it even has a Robert Redford connection — the star attended CU Boulder in his pre-fame days. The lack of quality Airbnbs is a bummer, but all things considered, I can live with it. THR’s Scott Feinberg says Boulder is the odds-on favorite, and though he notes some potential awareness around the preexisting Boulder International Film Festival held in March, he holds out hope for “some sort of an alliance that would keep all parties happy.” Redford’s daughter Amy is apparently helping out with the search, but I don’t think they’ll need to cajole her: In the eye of this beholder, it’s Boulder!

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